求英语高人翻译。。。。
The liver enzyme CYP2C19 is primarily responsible for the formation of the active metabolite of Plavix. Pharmacokinetic and antiplatelet tests of the active metabolite of Plavix show that the drug levels and antiplatelet effects differ depending on the genotype of the CYP2C19 enzyme. The following represent the different alleles of CYP2C19 that make up a patient's genotype:The CYP2C19*1 allele has fully functional metabolism of Plavix.
The CYP2C19*2 and *3 alleles have no functional metabolism of Plavix. These two alleles account for most of the reduced function alleles in patients of Caucasian (85%) and Asian (99%) descent classified as poor metabolizers.
The CYP2C19*4, *5, *6, *7, and *8 and other alleles may be associated with absent or reduced metabolism of Plavix, but are less frequent than the CYP2C19*2 and *3 alleles.
A patient with two loss-of-function alleles (as defined above) will have poor metabolizer status.
都是鸡肠,看不懂,机器翻译不全面。求高人翻译。。。 肝酶CYP2C19的主要负责对Plavix的活性代谢产物的形成负责。药代动力学和对Plavix的表明,抗血小板药物的水平和效果对不同CYP2C19基因活性代谢酶基因型不同抗血小板测试。下列代表CYP2C19基因构成一个病人的基因型不同的等位基因:
* 1等位基因的CYP2C19基因已完全Plavix的代谢功能。
该CYP2C19基因* 2和* 3等位基因有没有Plavix的代谢功能。这两个等位基因占等位基因的减少,功能最贫困代谢归类为白人(85%)和亚洲(99%)下降的病人。
该CYP2C19基因* 4,* 5,* 6,* 7,* 8以及其他可能与基因缺失或降低Plavix的新陈代谢,但比CYP2C19的那么频繁* 2和* 3等位基因。
一个与病人两个丢失功能等位基因(定义如上)将贫困代谢状态。 回复 2# 纸、
高人 谷歌在线翻译、、、 回复 4# 纸、
学到了 学到楼上的 谷歌翻译就可以啊 谷歌的翻译不全面。。。
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